Metabolism & Toxicity Services

Despite apparent improvements in drug attrition resulting from pharmacokinetic issues ^1,2, many promising test compounds still fail in development due to unforeseen side-effects or unfavorable pharmacokinetic profiles. Asterand can support lead optimization and pre-clinical development by performing a range of human tissue- and primary cell-based assays. Pre-clinical go/no-go decisions for drug candidates and formulations can be taken more reliably, improving the opportunity for enhanced success in clinical trials.

Asterand plc biochemical assays are also available via Assay Depot.    

Examples of standard metabolism & toxicity assays performed at Asterand are provided below. All assays are performed using fresh human tissue and / or using cells freshly isolated from human tissues.

• Hepatic metabolism
• Extrahepatic metabolism (lung & skin)
• Drug toxicity

Asterand's access to fresh human tissues from within our extensive network, combined with our experience and expertise in primary cell isolation, culture and assay development, allows us to perform a variety of metabolism & toxicity related assays. As with our other services, we welcome requests for developing custom assays.

For further information, contact us at advantage@asterand.com